Skincare trends come and go, but some ingredients gain attention because of the science behind them. PDRN is one of the newer ingredients making its way into serums, creams, masks and other skincare products. You may have already seen PDRN featured in viral Korean skincare products shared on TikTok or heard it described as a skin-repairing ingredient. But what exactly is PDRN, how does it work and how can you use it in your skincare routine?

Here is what you need to know about PDRN and PDRN-infused skincare products.

What Is PDRN?

PDRN stands for Polydeoxyribonucleotide. It is made up of purified DNA fragments and has been studied for its role in supporting tissue repair and regeneration.

PDRN has been used in medical and aesthetic settings, like in treatments focused on wound healing and skin regeneration. Its growing popularity in skincare has brought the ingredient into topical products designed to support healthier-looking skin.

In skincare, PDRN is commonly found in products such as;

• Serums

• Moisturisers

• Creams

• Facial masks

• Eye care products

• Ampoules

What Are the Potential Benefits of PDRN for Skin?

PDRN skincare products are generally used to support skin that needs hydration, barrier care and a smoother appearance. It should be noted that the concentration and formulation can vary between products, so the results you experience can also differ.

1. Supports Skin Repair

PDRN has been researched for its role in tissue regeneration and wound healing. In skincare, this has contributed to interest in its ability to support the skin's natural repair processes.

2. Helps Support the Skin Barrier

A healthy skin barrier helps maintain moisture and protects the skin from external irritants. PDRN is increasingly included in formulations designed to support skin that feels dry, sensitive or compromised.

3. Improves Hydration

Many PDRN products contain other hydrating ingredients, making them useful for adding moisture to the skin. Well-hydrated skin can appear smoother and more supple.

4. Supports Smoother-Looking Skin

With consistent skincare and adequate hydration, PDRN-infused products may help improve the overall appearance and texture of the skin.

5. Helps Support Healthy-Looking Skin as You Age

PDRN has attracted attention in anti-ageing skincare because of its connection with skin regeneration and repair. Products containing PDRN are often formulated alongside ingredients that support hydration and skin texture.

How to Use PDRN Skincare Products

PDRN can be incorporated into a skincare routine in several different ways, depending on the product.

If you are using a PDRN serum or ampoule, apply it after cleansing and toning and before your moisturiser. Follow the instructions provided with the specific product.

A simple routine could look like this the below

Can You Use PDRN With Other Skincare Ingredients?

PDRN can be found in formulations alongside ingredients such as hyaluronic acid, peptides, ceramides and niacinamide. These combinations can provide hydration and barrier support alongside the intended benefits of PDRN.

If your routine already contains strong active ingredients such as retinoids or exfoliating acids, introduce new products carefully. Using several active ingredients at once can increase the chance of irritation, particularly if your skin is sensitive. 

Our Top PDRN Skincare Picks

We have selected our best PDRN-infused products below. They combine PDRN with ingredients such as hyaluronic acid, peptides, collagen and centella asiatica to target hydration, elasticity, skin barrier support and radiance. 

Medicube PDRN Pink Peptide Serum

The Medicube PDRN Pink Peptide Serum combines 10,000 ppm Salmon PDRN with hyaluronic acid, niacinamide, turmeric and Coenzyme Q10 to support firmer, smoother and more hydrated-looking skin. Its formula is designed to improve elasticity, help reduce the appearance of dark spots and promote a more even complexion. Holy Basil extract also helps soothe the skin, making this a suitable option for sensitive skin types. With consistent use, the serum is designed to support improvements in skin texture and resilience.

Arencia PDRN Booster Shot

The Arencia PDRN Booster Shot is a lightweight recovery serum designed to give dull and tired-looking skin a hydrated, refreshed appearance. Its fast-absorbing formula helps improve the look of elasticity while providing lasting hydration without leaving a sticky finish. It also supports the skin barrier, making it a practical addition to both morning and evening routines. Use it when your skin needs extra hydration and a healthy-looking glow.

Centellian24 Expert Madeca Cream Active Renew PDRN

The Centellian24 Expert Madeca Cream Active Renew PDRN combines PDRN with the brand's Madeca approach, centred around Centella Asiatica and TECA. The cream is designed to support the skin barrier while providing lasting moisture and soothing dry, stressed skin. Its lightweight texture makes it suitable for daily use, particularly when your skin needs hydration and barrier support. It is a good choice for adding a moisturising PDRN product to your everyday routine.

Anua 100+ PDRN Hyaluronic Acid Capsule 100 Serum

The Anua 100+ PDRN Hyaluronic Acid Capsule 100 Serum brings together PDRN, hyaluronic acid and hydrolyzed collagen in a lightweight, emerald-toned formula. It provides multi-layer hydration while supporting smoother, plumper-looking skin and helping maintain a fresh, radiant complexion. The soothing texture makes it easy to incorporate into your routine throughout the year, especially when your skin needs additional moisture without a heavy finish.